The influence of the 'organizational factor' on compound quality in drug discovery

  title={The influence of the 'organizational factor' on compound quality in drug discovery},
  author={Paul D. Leeson and Stephen A. St-Gallay},
  journal={Nature Reviews Drug Discovery},
Physicochemical properties such as lipophilicity and molecular mass are known to have an important influence on the absorption, distribution, metabolism, excretion and toxicity (ADMET) profile of small-molecule drug candidates. To assess the use of this knowledge in reducing the likelihood of compound-related attrition, the molecular properties of compounds acting at specific drug targets described in patents from leading pharmaceutical companies during the 2000–2010 period were analysed. Over… CONTINUE READING
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