The influence of surface modification on the cytotoxicity of PAMAM dendrimers.

@article{Jevprasesphant2003TheIO,
  title={The influence of surface modification on the cytotoxicity of PAMAM dendrimers.},
  author={Rachaneekorn Jevprasesphant and Jeffrey Penny and Razieh Jalal and David Attwood and Neil B. McKeown and Antony D'Emanuele},
  journal={International journal of pharmaceutics},
  year={2003},
  volume={252 1-2},
  pages={263-6}
}
The influence of surface modification on the cytotoxicity of PAMAM dendrimers was examined using Caco-2 cells. Dendrimers were modified by conjugating either lauroyl chains or polyethylene glycol (PEG) 2000 onto the surface of cationic PAMAM dendrimers (G2, G3, G4). The cytotoxicity of unmodified dendrimers towards Caco-2 cells was appreciably higher for cationic (whole generation) compared with anionic (half generation) dendrimers and for both types increased with increasing size (generation… CONTINUE READING

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