The influence of some vasoactive drugs on bone circulation.

@article{Tran1978TheIO,
  title={The influence of some vasoactive drugs on bone circulation.},
  author={Michelle A Tran and J P G{\'e}ral},
  journal={European journal of pharmacology},
  year={1978},
  volume={52 1},
  pages={
          109-14
        }
}
We have studied the effect of various drugs on the intramedullary pressure in dog tibia after constant-flow autoperfusion of the nutrient artery by femoral arterial blood. The perfusion pressure and carotid arterial pressure were also recorded. Isoprenaline, acetylcholine, histamine, theophylline always lowered the perfusion pressure but had a variable effect on intramedullary pressure. This results from several factors e.g., perfusion pressure and intraosseous vasomotoricity. Adrenaline always… CONTINUE READING

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