The influence of smoking on the treatment response in patients with asthma

@article{Thomson2005TheIO,
  title={The influence of smoking on the treatment response in patients with asthma},
  author={Neil C Thomson and Mark Spears},
  journal={Current Opinion in Allergy and Clinical Immunology},
  year={2005},
  volume={5},
  pages={57–63}
}
  • N. Thomson, M. Spears
  • Published 1 February 2005
  • Medicine, Biology
  • Current Opinion in Allergy and Clinical Immunology
Purpose of reviewCigarette smoking and asthma are associated with poor symptom control and impaired therapeutic responses to corticosteroids. We summarize the clinical evidence for corticosteroid resistance, the mechanisms which could be responsible and potential management of this resistance. We also consider the effect smoking has on other drugs commonly used to treat patients with asthma. Recent findingsIn most developed countries the prevalence of active smoking in adults with asthma is… 

Differences in responses upon corticosteroid therapy between smoking and non-smoking patients with COPD.

The results support the evidence that inhaled corticosteroids have no anti-inflammatory effects in COPD patients, but only when these patients are still smoking.

Altered therapeutic response towards inhaled corticosteroids in asthmatics – smokers with mild asthma

More studies are needed in asthmatics determining the asthma symptom score, the number of night awakenings due to asthma, the asthma exacerbations and the frequency of rescue therapy usage which will define the altered therapeutic response to inhaled corticosteroids in smoking asthmatic patients.

Reduced corticosteroid sensitivity in smokers with asthma : potential mechanisms and treatment

The hypothesis that smokers with asthma displayed reduced responses to corticosteroids as a result of a cigarette smoke induced reduction in histone de-acetylase (HDAC) activity is examined, which suggests cigarette smoking in asthma may be associated with a deviation to Th1 mediated inflammation.

The Impact of Smoking on Clinical and Therapeutic Effects in Asthmatics

Asthmatic patients who were former or current smokers showed decreased pulmonary function and increased IgE, emphysema on HRCT, and fixed airway obstruction, indicating that smoking can modulate the clinical and therapeutic responses in asthma.

Corticosteroid Resistance and Novel Anti-Inflammatory Therapies in Chronic Obstructive Pulmonary Disease

Reversal of corticosteroid resistance in COPD patients by restoringHDAC2 levels has proved effective in a small study, and long-term studies are needed to determine whether novel HDAC2 activators or theophylline improve disease progression, exacerbations or mortality.

The Prevalence of Smoking among Sample of Kuwait Asthmatics and Its Impact on the Response of the Treatment

Smoking was associated with worse asthma control and poor compliance among asthmatics and there was a significant difference in symptoms and signs of bronchial asthma between the 2 groups.

Chapter 51 – Corticosteroids

Inhaled Corticosteroids

Inhaled corticosteroids are now first-line therapy for all patients with persistent asthma, controlling asthma symptoms and preventing exacerbations, although the high doses used in COPD has some systemic side effects and increases the risk of developing pneumonia.

References

SHOWING 1-10 OF 76 REFERENCES

Influence of cigarette smoking on inhaled corticosteroid treatment in mild asthma

Active cigarette smoking impairs the efficacy of short term inhaled corticosteroid treatment in mild asthma, and this finding has important implications for the management of patients with mild asthma who smoke.

Pharmacology of airway inflammation in asthma and COPD.

Cigarette smoking impairs the therapeutic response to oral corticosteroids in chronic asthma.

It is concluded that active smoking impairs the efficacy of short-term oral corticosteroid treatment in chronic asthma.

Active cigarette smoking and asthma

The effects of asthma on peripheral cell bloodcounts among smokers and non-smokers and their result suggest that smoking modifies the immunological response in asthma and this editorial will assess this new data in thelight of what is known about the clinical and immunologicaleffects of active smoking in adults with asthma.

Cigarette smoking and asthma symptom severity among adult asthmatics.

The data suggest that smoking hastens asthma progression or affects disease control, and the hazards associated with smoking among asthmatics need to be more clearly emphasized by physicians and public health officials in order to convince people with asthma who smoke to stop.

Smoking and airway inflammation in patients with mild asthma.

In addition to the eosinophilic airway inflammation observed in patients with asthma, smoking induces neutrophilicAirway inflammation; a relationship is apparent between smoking history, airwayinflammation, and lung function in smoking asthmatics.

How Do Corticosteroids Work in Asthma?

Understanding how corticosteroids work in patients with asthma may help in designing novel cortiosteroids with less systemic effects, as well as novel anti-inflammatory approaches, and help elucidate the molecular basis of chronic inflammation and why cortingosteroids are ineffective in Patients with steroid-resistant asthma and with chronic obstructive pulmonary disease.

Relationships of active smoking to asthma and asthma severity in the EGEA study. Epidemiological study on the Genetics and Environment of Asthma.

It is concluded that active smoking is not a risk factor for asthma in adulthood, but that smoking increases asthma severity.

The effect of cigarette smoking on exhaled nitric oxide in mild steroid-naive asthmatics.

The value of eNO as a marker of airway inflammation, at least in mild asthmatics who are already being treated with inhaled steroids or who are currently smoking is questioned.

Prednisolone response in patients with chronic obstructive pulmonary disease: results from the ISOLDE study

Patients with COPD cannot be separated into discrete groups of corticosteroid responders and non-responders, and prednisolone testing is an unreliable predictor of the benefit from inhaled fluticasone propionate in individual patients.
...