The influence of sex and histology on outcomes in non-small-cell lung cancer: a pooled analysis of five randomized trials.

@article{WheatleyPrice2010TheIO,
  title={The influence of sex and histology on outcomes in non-small-cell lung cancer: a pooled analysis of five randomized trials.},
  author={Paul Wheatley-Price and Fiona Blackhall and S Lee and Christodoulidou Ma and Linda Ashcroft and Mark Jitlal and Wendi Qian and Allan Hackshaw and Robin Rudd and Richard Booton and Sarah Danson and Paul C. Lorigan and Nicholas Thatcher and Frances A. Shepherd},
  journal={Annals of oncology : official journal of the European Society for Medical Oncology},
  year={2010},
  volume={21 10},
  pages={2023-8}
}
BACKGROUND Some non-small-cell lung cancer (NSCLC) surgical series have indicated that the positive prognostic effect of female sex is limited to patients with adenocarcinoma. We carried out a retrospective analysis to investigate the role of sex and histology on efficacy, toxicity, and dose delivery after chemotherapy. PATIENT AND METHODS Individual patient data were pooled from five randomized, phase III, advanced NSCLC chemotherapy trials. Primary outcomes were response rate, overall… CONTINUE READING

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