The influence of selected general anesthetics on pharmacokinetic parameters of some antiarrhythmic drugs in rabbits. Part IV. Lidocaine.

@article{OrszulakMichalak1995TheIO,
  title={The influence of selected general anesthetics on pharmacokinetic parameters of some antiarrhythmic drugs in rabbits. Part IV. Lidocaine.},
  author={Daria Orszulak-Michalak},
  journal={Acta poloniae pharmaceutica},
  year={1995},
  volume={52 4},
  pages={315-9}
}
The influence of selected general anesthetics: thiopental, propofol, ketamine and pentobarbital on the lidocaine pharmacokinetic parameters was studied in rabbits. Thiopental, ketamine and propofol caused a decrease of lidocaine blood level, but pentobarbital caused its increase. Pentobarbital, thiopental and ketamine caused an increase of lidocaine distribution rate constant, a decrease of its elimination rate constant, and prolongation of biological half-life. These anesthetics caused also an… CONTINUE READING
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