The influence of reduced oxygen availability on pathogenicity and gene expression in Mycobacterium tuberculosis.

@article{Bacon2004TheIO,
  title={The influence of reduced oxygen availability on pathogenicity and gene expression in Mycobacterium tuberculosis.},
  author={Joanna Bacon and Brian W. James and Lorenz Wernisch and Ann Williams and Kim A Morley and Graham J Hatch and Joseph A. Mangan and Jason Hinds and Neil G. Stoker and Philip D. Butcher and Philip David Marsh},
  journal={Tuberculosis},
  year={2004},
  volume={84 3-4},
  pages={205-17}
}
We investigated how Mycobacterium tuberculosis responded to a reduced oxygen tension in terms of its pathogenicity and gene expression by growing cells under either aerobic or low-oxygen conditions in chemostat culture. The chemostat enabled us to control and vary the oxygen tension independently of other environmental parameters, so that true cause-and-effect relationships of reduced oxygen availability could be established. Cells grown under low oxygen were more pathogenic for guinea pigs… CONTINUE READING

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