The influence of reactive oxygen species on cell cycle progression in mammalian cells.

@article{Verbon2012TheIO,
  title={The influence of reactive oxygen species on cell cycle progression in mammalian cells.},
  author={Eline Hendrike Verbon and Jan Andries Post and Johannes Boonstra},
  journal={Gene},
  year={2012},
  volume={511 1},
  pages={1-6}
}
Cell cycle regulation is performed by cyclins and cyclin dependent kinases (CDKs). Recently, it has become clear that reactive oxygen species (ROS) influence the presence and activity of these enzymes and thereby control cell cycle progression. In this review, we first describe the discovery of enzymes specialized in ROS production: the NADPH oxidase (NOX) complexes. This discovery led to the recognition of ROS as essential players in many cellular processes, including cell cycle progression… CONTINUE READING
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