The influence of quinidine and procaine amide on myocardial contractility in vivo.

@article{Angelakos1960TheIO,
  title={The influence of quinidine and procaine amide on myocardial contractility in vivo.},
  author={Evangelos Theodorou Angelakos and E P Hastings},
  journal={The American journal of cardiology},
  year={1960},
  volume={5},
  pages={
          791-8
        }
}
Normal Myocardial Contractile State in the Presence of Quinidine
TLDR
These studies suggest that quinidine does not directly affect myocardial contractility when given in therapeutic doses, and the reduction in heart rate in these animals provides support for a direct depressant effect of quInidine on the sinus node.
Depressant Effects of Quinidine Gluconate on Left Ventricular Function in Conscious Dogs with and Without Volume Overload
TLDR
It is concluded that quinidine causes depression of LV performance in normal dogs and in dogs with LV hypertrophy due to volume overload, and augmented sympathetic tone during qu inidine administration may mask these depressant effects.
A mechanism of quinidine-induced changes in the contraction force of guinea-pig atria
TLDR
It is found that there was always an increased contraction force if the drug concentration did not induce a persistent arrhythmia or abolish conducted events, and in addition to the typical changes of membrane characteristics, that the actions of quinidine on the contraction force of atria appears to be modified by stimulation frequency and catecholamines.
Comparative myocardial depressant effects of lidocaine, ajmalin, propranolol and quinidine.
TLDR
The combination of the direct myocardial depressant effects and beta blocking effects of propranolol suggest that this drug, as well as quinidine, must be used with caution in patients with heart failure.
Effect of quinidine on positive inotropic action of digoxin.
The cardiovascular effects of propanidid
TLDR
Study of the cardiovascuiar effects of propanidid with miniature radiotelemetric devices placed on surgical patients before the induction of anaesthesia finds the rapid return of the blood pressure to a normotensive level to be due to a blockade of the baroreceptors in the aortic arch and carotid arteries by the analgesic action of the drug.
Cardiac Function in Patients Treated with Phenothiazines. Comparison with Quinidine
TLDR
It is suggested that toxic or undesirable effects of PTH on the heart could be caused by one of the following mechanisms: depression of contractility, propensity to reentrant ventricular arrhythmias due to slow conduction and prolonged refractory period, and changes in automaticity due to direct effect on cardiac nerves.
...
...

References

SHOWING 1-10 OF 22 REFERENCES
The action of anesthetic agents on the loss of potassium from isolated guinea pig auricles.
  • W. Holland
  • Biology, Chemistry
    The Journal of pharmacology and experimental therapeutics
  • 1954
TLDR
It is postulated that the release and subsequent combination of acetylcholine with the receptor protein-cholinesterase is the process that normally accelerates ion movement across the myocardial membrane.
A possible mechanism of action of quinidine.
  • W. Holland
  • Biology
    The American journal of physiology
  • 1957
TLDR
Observations suggest that quinidine produces its effects by depressing outward flux of K ions by blocking the intracellularly released acetylcholine in a manner similar to low K.
Action of quinidine, procaine amide and other compounds on experimental atrial and ventricular arrhythmias in the dog.
  • M. Winbury, M. Hemmer
  • Chemistry, Medicine
    The Journal of pharmacology and experimental therapeutics
  • 1955
TLDR
The action of quinidine, procaine amide and five SC-compounds on experimental atrial and ventricular arrhythmias was investigated and all of the compounds increased the leffective refractory periodr of the isolated papillary muscle.
INFLUENCE OF PHARMACOLOGICAL AGENTS ON SPONTANEOUS AND SURGICALLY INDUCED HYPOTHERMIC VENTRICULAR FIBRILLATION *
  • E. Angelakos
  • Biology
    Annals of the New York Academy of Sciences
  • 1959
TLDR
A review of studies carried out in the laboratory with a variety of compounds over the last three years in attempts to delineate active agents, finding that study of the changes in the electrophysiological properties brought about by effective compounds may provide valuable clues as to the fundamental mechanisms that play a dominant role.
Relationships among stroke work, contractile force and fiber length during changes in ventricular function.
There is a linear relationship between ventricular contractile force and ventricular stroke work during changes in either atrial or aortic pressures and during the changes produced by l
Direct measurement of changes in cardiac contractile force; relationship of such measurements to stroke work, isometric pressure gradient and other parameters of cardiac function.
TLDR
Direct measurements of changes in the force of ventricular contraction with the strain gauge arch represent a sample of changesIn this study, the objective was to establish an experimental procedure and show direct measurements the strength of the contraction of the ventricular muscle.
...
...