The influence of potassium and chloride ions on the membrane potential of single muscle fibres

@article{Hodgkin1959TheIO,
  title={The influence of potassium and chloride ions on the membrane potential of single muscle fibres},
  author={Alan Lloyd Hodgkin and Paul Horowicz},
  journal={The Journal of Physiology},
  year={1959},
  volume={148}
}
The most widely accepted theory of the restirng potential of muscle is that the electrical potential difference between the inside and outside of a muscle fibre arises from the concentration gradients of the potassium and chloride ions. If we follow Boyle & Conway (1941), the membrane is assumed to be permeable to K and Cl but to be impermeable or sparingly permeable to other ions. Since K is more concentrated inside and Cl is more concentrated outside, the interior of the fibre should be… Expand
Chloride ions and the membrane potential of Purkinje fibres
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  • Chemistry, Medicine
  • The Journal of physiology
  • 1961
TLDR
The results suggest that the contribution of chloride ions to the total membrane conductance is low in a resting fibre but increases when a fibre is depolarized. Expand
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The membrane potential (Em) of sartorius muscle fibers was made insensitive to [K+] by equilibration in a 95 mM K+, 120 mM Na+ Ringer solution. Under these conditions a potassium-activated,Expand
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Reversal potentials (E IPSP) of the inhibitory postsynaptic potential and the membrane resting potentials (EM) of lobster muscle fibers were determined with intracellular recording under a variety ofExpand
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A series of experiments are considered which show that the difference in potassium concentration between the internal and external fluid provides the main electromotive force for generating the resting potential. Expand
Ionic basis of the resting potential of submucosal arterioles in the ileum of the guinea‐pig.
TLDR
It is suggested that at rest, arteriolar smooth muscle is permeant predominantly to potassium ions, with only small contributions from chloride and sodium ions. Expand
The chloride conductance of intermediate fibres from frog muscles.
  • H. Lorković
  • Chemistry, Medicine
  • General physiology and biophysics
  • 1987
TLDR
Measurements of the voltage displacement at constant current and of the current in a point voltage clamp showed that inwardly rectifying K channels were present in the membranes of both types of fibres, which may be explained by differences in the chloride conductance of the fast and intermediate fibre membranes. Expand
The action of calcium ions on potassium contractures of single muscle fibres
TLDR
Single fibres were used to achieve a quick change of the external ion concentrations, since a delay would have impeded the analysis of the time course of the transient contractures in twitch fibres. Expand
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This hypothesis is applied to the phenomena of subthreshold activity, accomodation and oscillatory behaviour and it is suggested that both permeability changes vary with membrane potential in a graded but reversible manner. Expand
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The results agree with the observations of Fenn & Cobb (1936) on mammalian muscle in showing that activity is associated with an entry of sodium ions and a somewhat smaller loss of potassium ions, and that labelled K+ and Na+ are lost exponentially from single muscle fibres. Expand
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TLDR
The present paper describes experiments in which the membrane potential of frog sartorius muscle was measured in solutions of different potassium content, and in solutions which were designed to alter the inside concentration of potassium keeping the outside concentration constant. Expand
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TLDR
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TLDR
The facts that the duration is greatly affected by the presence of, for example, iodide in the interspaces between the fibres, at a time when there is practically none of it inside the fibre, and that the effect rapidly passes off as iodide is removed from theInterspaces although a large amount of it may still be inside, are decisive evidence for the second view. Expand
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TLDR
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