The influence of polymer concentration on the 5-fluorouracil release rate from carbopol hydrogels.


5-Fluorouracil (5-FU) release kinetics from Carbopol 940 hydrogels prepared at pH 5.5 and five different polymer concentrations (0.0010, 0.0015, 0.0020, 0.0025 and 0.0030 w/w) were determined using Franz diffusion cells. Higuchi's equation for release from solutions was used to calculate the diffusion coefficients of 5-FU in the hydrogels. An empirical… (More)