The influence of paternal age on down syndrome.

  title={The influence of paternal age on down syndrome.},
  author={H. -U. Fisch and Grace Hyun and Robert Golden and Terry W. Hensle and Carl A. Olsson and Gary L. Liberson},
  journal={The Journal of urology},
  volume={169 6},
PURPOSE Children born to older parents are at greater risk for genetic abnormalities, such as Down syndrome. The influence of maternal age on Down syndrome is well established but little is known about the genetic consequences of advanced paternal age. MATERIALS AND METHODS Data on the incidence of Down syndrome from 1983 to 1997 (3,419 cases) were obtained from the New York State Department of Health congenital malformations registry. Parental age was modeled as individual age groups and by… CONTINUE READING