The influence of pH on antioxidant properties and the mechanism of antioxidant action of hydroxyflavones.

@article{Lemaska2001TheIO,
  title={The influence of pH on antioxidant properties and the mechanism of antioxidant action of hydroxyflavones.},
  author={Katarzyna Lemańska and Henryk Szymusiak and Bożena Tyrakowska and Rafalz Zieliński and Ans E. M. F. Soffers and Ivonne M C M Rietjens},
  journal={Free radical biology & medicine},
  year={2001},
  volume={31 7},
  pages={869-81}
}
The effect of the pH on antioxidant properties of a series of hydroxyflavones was investigated. The pKa of the individual hydroxyl moieties in the hydroxyflavones was compared to computer-calculated deprotonation energies. This resulted in a quantitative structure activity relationship (QSAR), which enables the estimation of pKa values of individual hydroxyl moieties, also in hydroxyflavones for which these pKa values are not available. Comparison of the pKa values to the pH-dependent… CONTINUE READING

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