The influence of ovarian hormones and of pregnancy on the action of some antimalarials on the isolated spontaneously contracting rat uterus.

@article{Abdelaziz1971TheIO,
  title={The influence of ovarian hormones and of pregnancy on the action of some antimalarials on the isolated spontaneously contracting rat uterus.},
  author={A. Abdel-aziz and M. Karrar and I. Idris},
  journal={European journal of pharmacology},
  year={1971},
  volume={16 2},
  pages={
          214-8
        }
}
Abstract The effects of the antimalarials quinine, chloroquine, chloroguanil and mepacrine on the isolated spontaneously contracting rat uterus under ovarian hormones treatment and during pregnancy were investigated. In uteri pretreated with oestradiol, quinine action was inconsistent, chloroquine increased the tonus and frequency of contractions, while chloroguanil and mepacrine were inhibitory. Progesterone treatment decreased the sensitivity of the rat uterus to the oxytocic action of… Expand
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