The influence of ouabain on twitch potentiation by anticholinesterases in the phrenic nerve-diaphragm muscles of mice.

@article{Nishimura1989TheIO,
  title={The influence of ouabain on twitch potentiation by anticholinesterases in the phrenic nerve-diaphragm muscles of mice.},
  author={Masakazu Obihiro-shi Nishimura and Hisakazu Ohtani and Osamu Yagasaki},
  journal={British journal of pharmacology},
  year={1989},
  volume={96 1},
  pages={
          179-85
        }
}
1. (+)-Tubocurarine, hexamethonium, atropine, ouabain, and removal of potassium from the bathing medium were examined for their effects on indirectly evoked twitches (IT) of mouse phrenic nerve-diaphragm muscles in the presence or absence of neostigmine. 2. Neostigmine increased the amplitude of IT. The twitch potentiation was reduced by (+)-tubocurarine at low concentrations that had no inhibitory effect on normal IT. Hexamethonium (10-100 microM), but not atropine (0.1-1 microM), partially… CONTINUE READING
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