The influence of natural antibody specificity on antigen immunogenicity.

@article{Benatuil2005TheIO,
  title={The influence of natural antibody specificity on antigen immunogenicity.},
  author={Lorenzo Benatuil and Joel Kaye and Robert F. Rich and Jay A Fishman and William Richard Green and John Iacomini},
  journal={European journal of immunology},
  year={2005},
  volume={35 9},
  pages={2638-47}
}
The natural antibody repertoire in humans, apes and Old World primates is distinct from the repertoire of all other placental mammals, and encodes antibodies specific for the carbohydrate epitope Galalpha1-3Galbeta1-4GlcNAc-R (alphaGal). Here, we examined whether conjugating antigens to the alphaGal epitope can augment their immunogenicity in alpha(1,3)galactosyltransferase knockout mice (GT0 mice) which, like humans, produce alphaGal-specific antibodies. Immunization of GT0 mice with BSA… CONTINUE READING
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