The influence of micro-topography on cellular response and the implications for silicone implants.

@article{Recum1995TheIO,
  title={The influence of micro-topography on cellular response and the implications for silicone implants.},
  author={Andreas F von Recum and Theo G. van Kooten},
  journal={Journal of biomaterials science. Polymer edition},
  year={1995},
  volume={7 2},
  pages={181-98}
}
Tissue attachment to substratum surfaces is of central importance to the in vivo performance of prosthetic implant materials. It is not yet understood why connective tissue does not attach to the surface of silicone or any other polymeric material. Recently the authors have conclusively demonstrated that micro-range surface roughness modifies cellular responses in cell culture and modifies biocompatibility and tissue attachment in vivo significantly. In order to better understand the basic… CONTINUE READING

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