The influence of metabolic and circulatory heterogeneity on the expression of pulmonary oxygen uptake kinetics in humans.

@article{Keir2015TheIO,
  title={The influence of metabolic and circulatory heterogeneity on the expression of pulmonary oxygen uptake kinetics in humans.},
  author={Daniel A Keir and T. Calloway Robertson and Alan P. Benson and Harry B Rossiter and J. Kowalchuk},
  journal={Experimental physiology},
  year={2015},
  volume={101 1},
  pages={
          176-92
        }
}
We examined the relationship amongst baseline work rate (WR), phase II pulmonary oxygen uptake (V̇(O2p)) time constant (τV̇(O2p)) and functional gain (G(P)=ΔV̇(O2p)/ΔWR) during moderate-intensity exercise. Transitions were initiated from a constant or variable baseline WR. A validated circulatory model was used to examine the role of heterogeneity in muscle metabolism (V̇(O2m)) and blood flow (Q̇(m)) in determining V̇(O2p) kinetics. We hypothesized that τV̇(O2p) and G(P) would be invariant in… CONTINUE READING
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