The influence of macrolide antibiotics on the uptake of organic anions and drugs mediated by OATP1B1 and OATP1B3.

@article{Seithel2007TheIO,
  title={The influence of macrolide antibiotics on the uptake of organic anions and drugs mediated by OATP1B1 and OATP1B3.},
  author={Annick Seithel and Sonja Eberl and Katrin Singer and Daniel Auge and Georg Heinkele and Nadine B Wolf and Frank D{\"o}rje and Martin F. Fromm and Joerg Koenig},
  journal={Drug metabolism and disposition: the biological fate of chemicals},
  year={2007},
  volume={35 5},
  pages={779-86}
}
Macrolides may cause severe drug interactions due to the inhibition of metabolizing enzymes. Transporter-mediated uptake of drugs into cells [e.g., by members of the human organic anion transporting polypeptide (OATP) family] is a determinant of drug disposition and a prerequisite for subsequent metabolism. However whether macrolides are also inhibitors of uptake transporters, thereby providing an additional mechanism of drug interactions, has not been systematically studied. The human OATP… CONTINUE READING