• Corpus ID: 23747374

The influence of local anesthetics on molecular organization in phosphatidylethanolamine membranes.

  title={The influence of local anesthetics on molecular organization in phosphatidylethanolamine membranes.},
  author={Eric Charles. Kelusky and Ian C. P. Smith},
  journal={Molecular pharmacology},
  volume={26 2},
The influence of the local anesthetics tetracaine (TTC) and procaine (PRC) on bilayers of specifically deuterated phosphatidylethanolamines (PE) has been studied by 2H and 31P NMR. Dimyristoylphosphatidylethanolamines (DMPE), deuterated at positions 2, 4, and 14 of the sn-2 chain, position 2 of the sn-1 chain, and in the ethanolamine headgroup, were mixed 1:1 with a semisynthetic egg PE and the effect of measured quantities of TTC and PRC on the 2H quadrupole splittings, spin-lattice relaxation… 
Tetracaine-membrane interactions: effects of lipid composition and phase on drug partitioning, location, and ionization.
It is proposed that the partitioning of tetracaine into solid-gel membranes is determined primarily by its steric accommodation between lipids, whereas in the liquid-crystalline membrane, in which the distance between lipid molecules is larger and steric hindrance is less important, hydrophobic and ionic interactions between Tetracaine and lipid molecules predominate.
Dibucaine interaction with phospholipid vesicles. A resonance energy-transfer study.
Dibucaine photophysics was studied and the short lifetime of the neutral form of the anaesthetic with respect to that of the monoprotonated species was attributed to an intramolecular charge-transfer interaction.
Molecular Details of Anesthetic‐Lipid Interaction a
By means of isotopic labeling with deuterium (2H) and observation by nuclear magnetic resonance (NMR), it has been possible to measure the conformational ordering and dynamics of lipids and