• DOI:10.1042/BST0300762
• Corpus ID: 14208156

The influence of iron homoeostasis on macrophage function.

@article{Ward2002TheIO,
  title={The influence of iron homoeostasis on macrophage function.},
  author={Roberta J. Ward and St{\'e}phanie Wilmet and Rachida Legssyer and Robert R. Crichton},
  journal={Biochemical Society transactions},
  year={2002},
  volume={30 4},
  pages={
          762-5
        }
}

• R. Ward, S. Wilmet, +1 author R. Crichton
• Published 1 August 2001
• Biology
• Biochemical Society transactions

Iron loading of alveolar macrophages in vivo significantly altered their ability to respond to various inflammatory stimuli. This was exemplified by reduced synthesis of inducible nitric oxide synthase after stimulus with lipopolysaccharide and interferon gamma, and an enhanced activation of nuclear factor kappa B in the absence of tumour necrosis factor alpha stimulation, and enhanced production of reactive oxygen species after activation with activated zymosan and PMA. Such results may indicate an imbalance in the production of reactive oxygen and reactive nitrogen species generated by the iron-loaded macrophages after an appropriate stimulus.