The influence of inadequate antimicrobial treatment of bloodstream infections on patient outcomes in the ICU setting.

@article{Ibrahim2000TheIO,
  title={The influence of inadequate antimicrobial treatment of bloodstream infections on patient outcomes in the ICU setting.},
  author={Emad H. Ibrahim and Glenda Sherman and Suzanne B. Ward and Victoria J. Fraser and Marin H. Kollef},
  journal={Chest},
  year={2000},
  volume={118 1},
  pages={
          146-55
        }
}
STUDY OBJECTIVE To evaluate the relationship between the adequacy of antimicrobial treatment for bloodstream infections and clinical outcomes among patients requiring ICU admission. DESIGN Prospective cohort study. SETTING A medical ICU (19 beds) and a surgical ICU (18 beds) from a university-affiliated urban teaching hospital. PATIENTS Between July 1997 and July 1999, 492 patients were prospectively evaluated. INTERVENTION Prospective patient surveillance and data collection. RESULTS… 
The influence of inadequate empirical antimicrobial treatment on patients with bloodstream infections in an intensive care unit.
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Almost a quarter of critically ill patients with bloodstream infections were given inadequate empirical antimicrobial treatment, but mortality was not higher in the group with inadequate treatment than in theGroup with adequate treatment, which was probably due to microbiological factors and clinical features.
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appropriate antimicrobial therapy administered to critically-ill patients presenting with bloodstream infections was associated with a lower 60-day mortality than inappropriate therapy, and survival time differed significantly between the two groups.
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The prescription of empirical antimicrobial Therapy by a senior physician in agreement with practice guidelines made it possible to achieve a crude rate of 89% of adequate antimicrobial therapy in study patients, which was associated with a 39% excess of mortality.
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Inappropriate initial antimicrobial therapy leads to higher mortality in patients with bloodstream infection and dose error and error in starting antimicrobial administration were the most frequently detected error in this study and both were determinant factors related to increased mortality.
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Inappropriate initial empirical antimicrobial treatment is associated with greater hospital mortality among patients with P. aeruginosa bloodstream infection and may be minimized by increased use of combination antimicrobial Treatment until susceptibility results become known.
Impact of Inappropriate Empiric Antimicrobial Therapy on Mortality of Septic Patients with Bacteremia: A Retrospective Study
TLDR
Higher mortality rates in bacteremic septic patients were substantially associated with inappropriate first-dose antimicrobials and 3-hour delayed antimicrobial administration after sepsis diagnosis.
ANTIMICROBIAL THERAPY IN CRITICALLY ILL PATIENTS WITH NOSOCOMIAL INFECTIONS
TLDR
The survival rate was higher in patients who received appropriate initial antimicrobial therapy and the results support the need for early appropriate antimicrobial treatment in critically ill patients with nosocomial infections.
Impact of inappropriate empiric antimicrobial therapy on mortality in pediatric patients with bloodstream infection: a retrospective observational study
TLDR
Investigation of the impact of an inappropriate empiric antibiotic therapy on mortality in pediatric patients with bloodstream infection found strategies to increase appropriate selection of empiric antibiotics might be an option for improving survival in Pediatrics.
Outcome of inadequate empirical antibiotic therapy in emergency department patients with community-onset bloodstream infections.
TLDR
Inadequate empirical antimicrobial therapy for community-onset BSI was associated with higher 30 day mortality rates and the magnitude of the adverse impact of inadequate antibiotic therapy decreased with the increasing severity of sepsis.
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References

SHOWING 1-10 OF 50 REFERENCES
Inadequate antimicrobial treatment of infections: a risk factor for hospital mortality among critically ill patients.
TLDR
Inadequate treatment of infections among patients requiring ICU admission appears to be an important determinant of hospital mortality, and clinical efforts aimed at reducing the occurrence of inadequate antimicrobial treatment could improve the outcomes of critically ill patients.
The influence of mini-BAL cultures on patient outcomes: implications for the antibiotic management of ventilator-associated pneumonia.
TLDR
It is suggested that antibiotic selection prior to obtaining the results of lower airway cultures is an important determinant of outcome for patients with suspected VAP, and a delay in initiating adequate antibiotic therapy was associated with a greater mortality.
Health and economic outcomes of antibiotic resistance in Pseudomonas aeruginosa.
TLDR
Efforts should be directed toward early detection and prevention of emergence of antibiotic resistance in Pseudomonas aeruginosa, which results in severe adverse outcomes.
The value of routine microbial investigation in ventilator-associated pneumonia.
TLDR
It is suggested that in patients with VAP, bronchoscopic results are frequently associated with changes in antibiotic therapy, and the critical importance of an appropriate early antibiotic therapy is emphasized.
Ventilator-associated pneumonia. A multivariate analysis.
TLDR
Potential interventions that might affect the incidence of VAP or outcome associated with VAP are suggested and indicate that different ICU populations may have different incidences of V AP.
Analysis of 1,186 episodes of gram-negative bacteremia in non-university hospitals: the effects of antimicrobial therapy.
TLDR
Findings confirm previous conclusions regarding the frequency and severity of gram-negative bacteremia and the overall impact of antimicrobial therapy on this condition and suggest the possibility that the definition of optimal initial therapy in some groups of patients should be reconsidered.
Nosocomial infections in medical intensive care units in the United States. National Nosocomial Infections Surveillance System.
TLDR
The distribution of sites of infection in medical ICUs differed from that previously reported in NNIS ICU surveillance studies, largely as a result of anticipated low rates of surgical site infections.
Enterobacter bacteremia: clinical features and emergence of antibiotic resistance during therapy.
TLDR
More judicious use of third-generation cephalosporins may decrease the incidence of nosocomial multiresistant Enterobacter spp.
Epidemiology and outcome of Pseudomonas aeruginosa bacteremia, with special emphasis on the influence of antibiotic treatment. Analysis of 189 episodes.
TLDR
The rate of P aeruginosa bacteremia is falling slightly and the administration of an appropriate antimicrobial therapy is essential to a good outcome, while treatment with 1 active antibiotic seems to be sufficient.
Impact of BAL data on the therapy and outcome of ventilator-associated pneumonia.
TLDR
The impact of BAL data on the selection of antibiotics and the outcomes of patients with ventilator-associated pneumonia (VAP) is defined and mortality rate is reduced if this empiric therapy is adequate, compared to when this therapy is inadequate or no therapy is given.
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