The influence of immuosuppressive therapy on the development of CD4+CD25+ T cells after renal transplantation.

@article{KorczakKowalska2007TheIO,
  title={The influence of immuosuppressive therapy on the development of CD4+CD25+ T cells after renal transplantation.},
  author={Grażyna Korczak-Kowalska and Piotr Wierzbicki and Katarzyna Bocian and Danuta Klosowska and Mariusz Niemczyk and Janusz Wyzgal and Anna Korecka and Magdalena Durlik and Andrzej Chmura and Leszek Paczek and Andrzej G{\'o}rski},
  journal={Transplantation proceedings},
  year={2007},
  volume={39 9},
  pages={2721-3}
}
A growing number of studies suggest that CD4(+)CD25(+) T regulatory (Treg) cells play a significant role to downregulate the immune response to alloantigens. In this study, we investigated the possible influence of immunosuppressive therapy, including cyclosporine (CsA) or rapamycin (sirolimus), on the level of CD4(+)CD25(+), CD4(+)CD25(+)FOXP3(+), and CD4(+)CD25(+)CTLA-4(+) T cells in the peripheral blood of renal allograft recipients. The study was performed on renal allograft recipients who… CONTINUE READING

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