The influence of immaturity on hypoxic-ischemic brain damage in the rat.

@article{Rice1981TheIO,
  title={The influence of immaturity on hypoxic-ischemic brain damage in the rat.},
  author={Joseph E. Rice and Robert C. Vannucci and J. B. Brierley},
  journal={Annals of neurology},
  year={1981},
  volume={9 2},
  pages={131-41}
}
Brain damage in the Levine preparation (unilateral common carotid artery ligation with hypoxia) consists of ischemic neuronal alterations in the ipsilateral forebrain. As the model has been restricted to adult animals, unilateral common carotid artery ligation was carried out in 7-day-postnatal rats. Four to 8 hours later the 25 pups were exposed to 8% oxygen at 37 degrees C for 3.5 hours. Controls consisted of littermates subjected to carotid ligation without subsequent hypoxia, hypoxia… CONTINUE READING
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