The influence of high-energy shock waves on the development of metastases.

  title={The influence of high-energy shock waves on the development of metastases.},
  author={Gosse O. N. Oosterhof and Erik Bastiaan Cornel and Geert A. H. J. Smits and Frans M. J. Debruyne and Jack A Schalken},
  journal={Ultrasound in medicine & biology},
  volume={22 3},
The hypothesis that exposure of a solid tumor to high-energy shock waves (HESW) could lead to an increase of metastases was investigated in an animal model. The highly metastatic AT-6 Dunning R3327 rat prostate cancer subline was implanted in the hind limb of a Fisher-Copenhagen rat and was exposed to 6000 shock waves delivered by an experimental lithotripter, or sham-treated, as soon as the tumor had reached a volume of 175-225 mm3. The tumor-bearing leg was amputated 24 h later and the number… CONTINUE READING

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