The influence of heterocyclic compound-PAMAM dendrimer complexes on evoked electrical responses in slices of hypoxic brain tissue

Abstract

We used complexes between a fourth generation polyamidoamine (PAMAM) dendrimer and one of two heterocyclic compounds — 1-(6-hydroxyhexyl)-3-(5-phenyl-isoxazole-3-yl)-urea or 5-phenyl-isoxazole-3-carboxylic acid — to reduce oxygen consumption in transverse slices of the hippocampus taken from 4-week old male rats. In vitro electrophysiological experiments revealed that the inhibitory effect of the hypoxic state on the evoked responses was enhanced in the presence of the complexes. The data were analyzed in terms of the potential antitumor effects of these complexes.

DOI: 10.2478/s11658-014-0193-5

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@article{Potkin2014TheIO, title={The influence of heterocyclic compound-PAMAM dendrimer complexes on evoked electrical responses in slices of hypoxic brain tissue}, author={Vladimir I. Potkin and Dzmitry Shcharbin and Andrey A. Denisov and Svetlana G. Paschkevich and Maria J Bryszewska and Sergey K. Petkevich and Alexey V. Kletskov and Dmitri O. Lapotko and Vladimir V. Kazbanov and Tatiana A. Gurinovich and Vladimir A. Kulchitsky}, journal={Cellular & Molecular Biology Letters}, year={2014}, volume={19}, pages={243-248} }