The influence of gut-decontamination prophylactic antibiotics on acute graft-versus-host disease and survival following allogeneic hematopoietic stem cell transplantation.

@article{Routy2017TheIO,
  title={The influence of gut-decontamination prophylactic antibiotics on acute graft-versus-host disease and survival following allogeneic hematopoietic stem cell transplantation.},
  author={Bertrand Routy and Caroline Letendre and David Pierre Enot and Maxime Ch{\'e}nard-Poirier and Vikram Mehraj and No{\'e}mie Charbonneau S{\'e}guin and Khaled Guenda and Kathia Gagnon and Paul-Louis Woerther and David Ghez and Silvy Lachance},
  journal={Oncoimmunology},
  year={2017},
  volume={6 1},
  pages={e1258506}
}
The intestinal microbiota plays a key role in the pathogenesis of acute graft-versus-host disease (aGVHD). High-dose conditioning regimens given prior to allogeneic hematopoietic stem cell transplantation (aHSCT) modulate the composition of gut microbiota and damage the gut epithelial barrier, resulting in increased systemic inflammation. We assessed… CONTINUE READING