The influence of genetic background on the induction of oxidative stress and impaired insulin secretion in mouse islets

@article{Zraika2006TheIO,
  title={The influence of genetic background on the induction of oxidative stress and impaired insulin secretion in mouse islets},
  author={Sakeneh Zraika and Kathryn Aston-Mourney and D. Ross Laybutt and Melkam Kebede and Marjorie E. Dunlop and J. Proietto and Sofianos Andrikopoulos},
  journal={Diabetologia},
  year={2006},
  volume={49},
  pages={1254-1263}
}
We determined whether high-glucose-induced beta cell dysfunction is associated with oxidative stress in the DBA/2 mouse, a mouse strain susceptible to islet failure. Glucose- and non-glucose-mediated insulin secretion from the islets of DBA/2 and control C57BL/6 mice was determined following a 48-h exposure to high glucose. Flux via the hexosamine biosynthesis pathway was assessed by determining O-glycosylated protein levels. Oxidative stress was determined by measuring hydrogen peroxide levels… CONTINUE READING
26 Citations
49 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 26 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 49 references

Similar Papers

Loading similar papers…