The influence of gangliosides on the hydrophilic pore edge line tension and monolayer fusion of lipid membranes.

@article{Melikyan1990TheIO,
  title={The influence of gangliosides on the hydrophilic pore edge line tension and monolayer fusion of lipid membranes.},
  author={Grigory B. Melikyan and N S Matinyan and V. B. Arakelian},
  journal={Biochimica et biophysica acta},
  year={1990},
  volume={1030 1},
  pages={11-5}
}
It is shown that inclusion of gangliosides into planar phospholipid bilayers leads to an essential suppression of their monolayer fusion. In contrast to phospholipid lysoforms, the gangliosides do not cause an associative decrease of the specific energy of the hydrophilic pore edge determined in the experiments on the electrical breakdown of membranes. This phenomenon depends on the effective size of the polar headgroup of the gangliosides. It is supposed that the effect of gangliosides on the… CONTINUE READING

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