The influence of fluticasone inhalation on premalignant lesions in the bronchial epithelium of a high risk population: A double blind placebo-controlled randomised phase II study.

@article{Berg2006TheIO,
  title={The influence of fluticasone inhalation on premalignant lesions in the bronchial epithelium of a high risk population: A double blind placebo-controlled randomised phase II study.},
  author={Ren{\'e} van den Berg and Harm van Tinteren and Nico van Zandwijk and Thomas G. Sutedja and Paul Baas and Caroline Elisabeth Visser and Katharina Gruenberg and Wolter J. Mooi and Pieter E Postmus and Egbert Frederik Smit},
  journal={Journal of clinical oncology : official journal of the American Society of Clinical Oncology},
  year={2006},
  volume={24 18_suppl},
  pages={7200}
}
7200 Background: Bronchial epithelium exposed to cigarette smoke undergoes a series of histological changes that may ultimately lead to invasive cancer. In rats exposed to cigarette smoke inhaled corticosteroids reduce the number of lung tumors. We studied the effect of fluticasone on premalignant lesions in volunteers with a smoking history of ≥10 pack-years and patients cured of head and neck cancer or lung cancer. METHODS Participants were screened for premalignant lesions by bronchoscopy… CONTINUE READING