The influence of fluorescent dye structure on the electrophoretic mobility of end-labeled DNA.

@article{Tu1998TheIO,
  title={The influence of fluorescent dye structure on the electrophoretic mobility of end-labeled DNA.},
  author={O. Tu and Th. Knott and May Marsh and Kathleen B. Bechtol and Dennis L. Harris and Daniel Keith Barker and John S. Bashkin},
  journal={Nucleic acids research},
  year={1998},
  volume={26 11},
  pages={
          2797-802
        }
}
Over the past 10 years, fluorescent end-labeling of DNA fragments has evolved into the preferred method of DNA detection for a wide variety of applications, including DNA sequencing and PCR fragment analysis. One of the advantages inherent in fluorescent detection methods is the ability to perform multi-color analyses. Unfortunately, labeling DNA fragments with different fluorescent tags generally induces disparate relative electrophoretic mobilities for the fragments. Mobility-shift… CONTINUE READING

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