The influence of finasteride on the development of prostate cancer.

  title={The influence of finasteride on the development of prostate cancer.},
  author={Ian M. Thompson and Phyllis J. Goodman and Catherine M. Tangen and M. Scott Lucia and Gary J. Miller and Leslie G. Ford and Michael M. Lieber and R. Duane Cespedes and James Norman Atkins and Scott Michael Lippman and Susie M Carlin and Anne L Ryan and Connie M. Szczepanek and John J. Crowley and Charles Arthur Coltman},
  journal={The New England journal of medicine},
  volume={349 3},
BACKGROUND Androgens are involved in the development of prostate cancer. Finasteride, an inhibitor of 5alpha-reductase, inhibits the conversion of testosterone to dihydrotestosterone, the primary androgen in the prostate, and may reduce the risk of prostate cancer. METHODS In the Prostate Cancer Prevention Trial, we randomly assigned 18,882 men 55 years of age or older with a normal digital rectal examination and a prostate-specific antigen (PSA) level of 3.0 ng per milliliter or lower to… CONTINUE READING
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