The influence of extracellular acidosis on the effect of IKr blockers.


BACKGROUND Myocardial infarction causes the acidification of the cellular environment and the resultant acidosis maybe arrhythmogenic. The effect of acidosis on the action of antiarrhythmic drugs, an important issue in the antiarrhythmic drug therapy after myocardial infarction, remains to be studied. METHODS To evaluate the effect of acidosis on… (More)


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