The influence of esterification on the topical antiinflammatory activity of 7 alpha-chloro- and 7 alpha-bromo-16 alpha-methylprednisolones.

Abstract

The effect on topical antiinflammatory potency of altering the ester functions of 7-halogenocorticosteroids was examined. Highest potencies for both 7 alpha-chloro- and 7 alpha-bromo-16 alpha-methylprednisolones were generally achieved through diesterification at the 17- and 21-positions. However, among these diesters, structure seems to be more important… (More)

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@article{Green1980TheIO, title={The influence of esterification on the topical antiinflammatory activity of 7 alpha-chloro- and 7 alpha-bromo-16 alpha-methylprednisolones.}, author={M. J. Green and Hao J Shue and Riccardo Tiberi and Joseph W. Berkenkopf and Ximena Fern{\'a}ndez and M Monahan and Barry N. Lutsky}, journal={Arzneimittel-Forschung}, year={1980}, volume={30 10}, pages={1618-20} }