The influence of epileptic neuropathology and prior peripheral immunity on CNS transduction by rAAV2 and rAAV5

@article{Weinberg2011TheIO,
  title={The influence of epileptic neuropathology and prior peripheral immunity on CNS transduction by rAAV2 and rAAV5},
  author={Marc S Weinberg and Bonnie L. Blake and Richard Jude Samulski and Thomas J. McCown},
  journal={Gene Therapy},
  year={2011},
  volume={18},
  pages={961-968}
}
Adeno-associated virus (AAV) provides a promising platform for clinical treatment of neurological disorders owing to its established efficacy and lack of apparent pathogenicity. To use viral vectors in treating neurological disease, however, transduction must occur under neuropathological conditions. Previous studies in rodents have shown that AAV5 more… CONTINUE READING