The influence of endothelium-derived nitric oxide on myocardial contractile function.

@article{Shah1995TheIO,
  title={The influence of endothelium-derived nitric oxide on myocardial contractile function.},
  author={Ajay M. Shah and Bernard D. Prendergast and Richard Grocott-Mason and Malcolm J. Lewis and Walter Paulus},
  journal={International journal of cardiology},
  year={1995},
  volume={50 3},
  pages={225-31}
}
Nitric oxide released by cardiac endothelial cells modulates myocardial contractile function through elevation of intracellular 3',5'-cyclic guanosine monophosphate (cGMP). In the absence of agonist stimulation, nitric oxide typically enhances myocardial relaxation and reduces diastolic tone, without significantly altering the rate of force or pressure development. This pattern of effect is observed with nitric oxide or with cGMP analogues in isolated rat cardiac myocytes, isolated ferret… CONTINUE READING
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