The influence of endosome-disruptive peptides on gene transfer using synthetic virus-like gene transfer systems.

@article{Plank1994TheIO,
  title={The influence of endosome-disruptive peptides on gene transfer using synthetic virus-like gene transfer systems.},
  author={Christian Plank and Berndt Oberhauser and Karl Mechtler and Christian Koch and Elsa Wagner},
  journal={The Journal of biological chemistry},
  year={1994},
  volume={269 17},
  pages={12918-24}
}
The process by which viruses destabilize endosomal membranes in an acidification-dependent manner has been mimicked with synthetic peptides that are able to disrupt liposomes, erythrocytes, or endosomes of cultured cells. Peptides containing the 20 amino-terminal amino acid sequence of influenza virus hemagglutinin as well as acidic derivatives showed erythrocyte lysis activity only when peptides were elongated by an amphipathic helix or by carboxyl-terminal dimerization. Interestingly… CONTINUE READING