The influence of endocrine disruptors on pubertal timing

  title={The influence of endocrine disruptors on pubertal timing},
  author={Elka E Jacobson-Dickman and Mary M. Lee},
  journal={Current Opinion in Endocrinology, Diabetes and Obesity},
Purpose of reviewOverview of the effects of endocrine disruptors on pubertal timing. Recent findingsEpidemiologic studies in humans support animal data demonstrating that exposures to endocrine-disrupting compounds have pronounced effects on pubertal timing and that the timing of endocrine-disrupting compound exposure and the specific agent causes different outcomes. Recent studies confirm subtle effects of lead, dioxins, and phytoestrogens on delaying onset of puberty and demonstrate an… 
The Influence of Endocrine Disruptors on Male Pubertal Timing
In conclusion, animal and human data confirm perturbations in pubertal onset and attainment of late Pubertal stages with early-life exposures to EDCs.
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Effects of Environmental Endocrine Disruptors on Pubertal Development
  • S. ÖzenS. Darcan
  • Biology, Medicine
    Journal of clinical research in pediatric endocrinology
  • 2011
The available evidence from animal and human studies on the effects of environmental EDs with the potential to cause precocious or delayed puberty was reviewed.
Male pubertal development: are endocrine-disrupting compounds shifting the norms?
The normal process of puberty in males is reviewed and human data that suggest potential perturbations in pubertal onset and tempo with early-life exposures to EDCs are summarized.
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Due to ubiquity of endocrine disrupters and lifelong stakes of early exposure, individual families should be provided by pediatricians with recommendations following the precautionary principle, that is prevention or attenuation of conditions possibly detrimental to health before the evidence of such adverse effects is complete and undisputable.
Thyroid Hormone Regulation of Mammalian Reproductive Development and the Potential Impact of Endocrine-Disrupting Chemicals
An analysis of the evidence linking thyroidal disruption by polychlorinated biphenyl, polybrominated diphenyl ether, phthalate, triclosan, and bisphenol A exposure, with maldevelopment of mammalian reproductive systems is provided.
Association Between Urinary Phthalates and Pubertal Timing in Chinese Adolescents
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In utero and peripubertal metals exposure in relation to reproductive hormones and sexual maturation and progression among boys in Mexico City
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Effect of endocrine disruptor phytoestrogens on the immune system: Present and future.
  • G. Csaba
  • Biology
    Acta microbiologica et immunologica Hungarica
  • 2018
Phytoestrogen's effects appear in the progeny generations, and the generationally repeated disruptor effects will be different from the present ones, and this could also be manifested in the amount, type, and appearance of autoimmune diseases.


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There is increasing evidence for a link between prenatal development and pubertal onset, and the causal pathways and the molecular mechanisms that may link the Pubertal growth pattern of children born SGA, puberal development and endocrine-disrupting chemicals need further study.
Endocrine-Disrupting Chemicals: Prepubertal Exposures and Effects on Sexual Maturation and Thyroid Function in the Male Rat. A Focus on the EDSTAC Recommendations
The existing data indicate that this assessment of puberty in the male rat is a simple and effective method to detect the EDC activity of pesticides and toxic substances.
Study of neonatal exposure to androgenic endocrine disruptors, testosterone and dihydrotestosterone by normal-phase HPLC.
Neonatal exposure to androgen induces developmental abnormalities in the male reproductive system. To investigate whether neonatal exposure affects spermatogenesis in juvenile and pubertal testis,
Environmental Factors and Puberty Timing: Expert Panel Research Needs
The panel concluded that available experimental animal and human data support a possible role of endocrine-disrupting chemicals and body size in relation to alterations in pubertal onset and progression in boys and girls.
Endocrine-Disrupting Chemicals: Prepubertal Exposures and Effects on Sexual Maturation and Thyroid Activity in the Female Rat. A Focus on the EDSTAC Recommendations
This review focuses specifically on the revised in vivo screening procedure recommended under the title Research Protocol for Assessment of Pubertal Development and Thyroid Function in Juvenile Female Rats.
Effects on pubertal growth and reproduction in rats exposed to lead perinatally or continuously throughout development.
Delayed female reproductive development and suppression of adult male serum testosterone concentration required continuous exposure to the heavy metal, and exposure during early development (pregnancy and lactation) resulted in no permanent effects in this model.
Dioxin Exposure, from Infancy through Puberty, Produces Endocrine Disruption and Affects Human Semen Quality
Exposure to TCDD in infancy reduces sperm concentration and motility, and an opposite effect is seen with exposure during puberty, which is within one order of magnitude of those in the industrialized world in the 1970s and 1980s and may be responsible for the reported decrease in sperm quality.