The influence of drug-like concepts on decision-making in medicinal chemistry
@article{Leeson2007TheIO, title={The influence of drug-like concepts on decision-making in medicinal chemistry}, author={P. Leeson and Brian Springthorpe}, journal={Nature Reviews Drug Discovery}, year={2007}, volume={6}, pages={881-890} }
The application of guidelines linked to the concept of drug-likeness, such as the 'rule of five', has gained wide acceptance as an approach to reduce attrition in drug discovery and development. However, despite this acceptance, analysis of recent trends reveals that the physical properties of molecules that are currently being synthesized in leading drug discovery companies differ significantly from those of recently discovered oral drugs and compounds in clinical development. The consequences… CONTINUE READING
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- 2010
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- 2015
- 8
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References
SHOWING 1-10 OF 63 REFERENCES
Drug-like properties: guiding principles for design - or chemical prejudice?
- Computer Science, Medicine
- Drug discovery today. Technologies
- 2004
- 63
A guide to drug discovery: The role of the medicinal chemist in drug discovery — then and now
- Engineering, Medicine
- Nature Reviews Drug Discovery
- 2004
- 201
- PDF
Lead- and drug-like compounds: the rule-of-five revolution.
- Biology, Medicine
- Drug discovery today. Technologies
- 2004
- 1,776
A comparison of physiochemical property profiles of development and marketed oral drugs.
- Chemistry, Medicine
- Journal of medicinal chemistry
- 2003
- 426
Analysis of Pharmacology Data and the Prediction of Adverse Drug Reactions and Off‐Target Effects from Chemical Structure
- Medicine
- ChemMedChem
- 2007
- 266
Identification and evaluation of molecular properties related to preclinical optimization and clinical fate.
- Computer Science, Medicine
- Medicinal chemistry (Shariqah (United Arab Emirates))
- 2005
- 33
Analysis of drug-induced effect patterns to link structure and side effects of medicines
- Biology, Medicine
- Nature chemical biology
- 2005
- 137
- PDF
Characteristic physical properties and structural fragments of marketed oral drugs.
- Chemistry, Medicine
- Journal of medicinal chemistry
- 2004
- 309
Predicting ADME properties and side effects: the BioPrint approach.
- Computer Science, Medicine
- Current opinion in drug discovery & development
- 2003
- 158