The influence of drug-like concepts on decision-making in medicinal chemistry

@article{Leeson2007TheIO,
  title={The influence of drug-like concepts on decision-making in medicinal chemistry},
  author={Paul D. Leeson and Brian Springthorpe},
  journal={Nature Reviews Drug Discovery},
  year={2007},
  volume={6},
  pages={881-890}
}
The application of guidelines linked to the concept of drug-likeness, such as the 'rule of five', has gained wide acceptance as an approach to reduce attrition in drug discovery and development. However, despite this acceptance, analysis of recent trends reveals that the physical properties of molecules that are currently being synthesized in leading drug discovery companies differ significantly from those of recently discovered oral drugs and compounds in clinical development. The consequences… 
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