The influence of dolichol, dolichol esters, and dolichyl phosphate on phospholipid polymorphism and fluidity in model membranes.

@article{Valtersson1985TheIO,
  title={The influence of dolichol, dolichol esters, and dolichyl phosphate on phospholipid polymorphism and fluidity in model membranes.},
  author={C. Valtersson and G. van Du{\"y}n and A. Verkleij and T. Chojnacki and B. de Kruijff and G. Dallner},
  journal={The Journal of biological chemistry},
  year={1985},
  volume={260 5},
  pages={
          2742-51
        }
}
The effect of dolichols, polyprenols, dolichol esterified with fatty acids, and dolichyl phosphate on the structure and fluidity of model membranes was studied using 31P NMR, small-angle x-ray scattering, differential scanning calorimetry, and freeze-fracture electron microscopy. These studies suggest that dolichol and dolichol derivatives destabilize unsaturated phosphatidylethanolamine containing bilayer structures and promote hexagonal II phase formation; high concentrations of dolichol… Expand
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