The influence of disodium ethane-1-hydroxy-1,1-diphosphonate (EHDP) on the development of experimentally induced urinary stones in rats.

@article{Fraser1972TheIO,
  title={The influence of disodium ethane-1-hydroxy-1,1-diphosphonate (EHDP) on the development of experimentally induced urinary stones in rats.},
  author={D. Fraser and R. Graham G. Russell and Ortrun E. M. Pohler and William G. Robertson and Herbert Fleisch},
  journal={Clinical science},
  year={1972},
  volume={42 2},
  pages={
          197-207
        }
}
1. Bladder stones composed of calcium hydrogen phosphate dihydrate, calcium oxalate mono- and di-hydrate and magnesium ammonium phosphate hexahydrate (struvite) were successfully induced in rats by various dietary manipulations and by implanting zinc pellets in the bladder. 2. The effect of a diphosphonate, disodium ethane-1-hydroxy-1,1-diphosphonate (EHDP), given in the drinking water at concentrations of 0·0025, 0·05 and 0·5% (w/v), on the size and composition of these stones was examined. 3… 
HYDROXY-1,l-DIPHOSPHONATE (EHDP) ON THE DEVELOPMENT OF EXPERIMENTALLY INDUCED URINARY STONES IN RATS
SUMMARY 1. Bladder stones composed of calcium hydrogen phosphate dihydrate, calcium oxalate mono- and di-hydrate and magnesium ammonium phosphate hexahydrate (struvite) were successfully induced in
THE EFFECT OF ETHANE-1-HYDROXY-1 , l - DIPHOSPHONATE (EHDP) O N CALCIUM OXALATE FORMERS
1. The volume, size and type of calcium oxalate crystals excreted in the urine of a group of patients with recurrent ‘idiopathic’ stones were studied on a controlled basal diet, after an oral
THE EFFECT OF E THANE-1-HYDR OXY-1,l- DIPHOSPHONATE (EHDP) ON CALCIUM OXALATE FORMERS CRYSTALLURIA IN RECURRENT RENAL STONE-
SUMMARY 1. The volume, size and type of calcium oxalate crystals excreted in the urine of a group of patients with recurrent ‘idiopathic’ stones were studied on a controlled basal diet, after an oral
Biochemical and clinical effects of ethane-1-hydroxy-1,1-diphosphonate in calcium nephrolithiasis.
1. The short- and longer-term effects of ethane-1-hydroxy-1,1-diphosphonate (EHDP), an inhibitor of crystal growth and potential preventive agent against urinary tract stones in man, have been
The effect of diphosphonate on calcium phosphate crystallization in urine in vitro.
TLDR
Disodium ethane-1-hydroxy-1, 1-diphosphonate was added to human urine in vitro and tested for its effect on nucleation, crystal growth and crystal dissolution of brushite, the probable nidus for certain calcium-containing renal stones.
The influence of two diphosphonates on calcium metabolism in the rat.
TLDR
EHDP was more potent in decreasing bone turnover than C1,MDP, but the two compounds caused a similar increase in the retention of calcium, and at high doses EHDP inhibited the mineralization of epiphyseal cartilage.
Inhibition of calcium oxalate urolithiasis in a rat model of lithogenesis using bisphosphonates.
TLDR
Older and newer-generation bisphosphonates have an inhibitory effect on calcium oxalate urolithiasis that is demonstrable at relatively infrequent dosing intervals in vivo, and more frequent dosing or higher doses may allow greater inhibition of stone formation.
THE INFLUENCE O F TWO DIPHOSPHONATES ON CALCIUM METABOLISM I N THE RAT
1. The effects of two diphosphonates, disodium ethane-I-hydroxy-l,1-diphosphonate (EHDP) and disodium dichloromethylene diphosphonate (C1,MDP) on several variables of calcium metabolism have been
Effeet of ethane-1-hydroxy-1-, 1-diphosphonate /EHDP/ on the amount and crystallinity of bone mineral in growing and adult rats
TLDR
The observed differences in the effect of EHDP on young and adult animals confirm the conclusion that the action of the drug depends strongly on bone turnover.
Aggregation of calcium oxalate crystals: Effect of urine and various inhibitors
TLDR
Study by means of heat inactivation, ultrafiltration and fractionation on DEAE-cellulose and gel-filtration indicated that the inhibitory activity was heterogenous and that the major part was larger than 10000 daltons.
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