The influence of dimethoxybenfluron on biochemical and haematological parameters in rabbits.

@article{Machckov1999TheIO,
  title={The influence of dimethoxybenfluron on biochemical and haematological parameters in rabbits.},
  author={Jarmila Mach{\'a}ckov{\'a} and Vladimír Geršl and Radom{\'i}r Hrdina and Milan Nobilis and Vladim{\'i}r Pali{\vc}ka},
  journal={Acta medica},
  year={1999},
  volume={42 3},
  pages={
          89-92
        }
}
The influence of repeated i.v. administration of dimethoxybenfluron (NO-1-B) (12 or 24 mg base/kg once weekly, 10 weeks) on biochemical and haematological parameters were studied in rabbits in vivo. No significant changes were mostly found in the serum ion levels between the dimethoxybenfluron and the control groups, as well as in most of other biochemical parameters (including total protein and albumin levels). Nevertheless, the lower dose of dimethoxybenfluron caused an increase in the… 
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Evaluation of cardiac effects of the new antineoplastic drug --dimethoxybenfluron--in the rabbit.
TLDR
The lack of cardiotoxicity of this new antineoplastic drug was supported by the absence of alterations in PEP:LVET ratio, left ventricle dP/dtmax or histological heart examination as well as by the fact that no premature death of animals occurred following repeated administration of dimethoxybenfluron.