The influence of dietary fat on insulin resistance

@article{Lovejoy2002TheIO,
  title={The influence of dietary fat on insulin resistance},
  author={Jennifer C. Lovejoy},
  journal={Current Diabetes Reports},
  year={2002},
  volume={2},
  pages={435-440}
}
  • J. Lovejoy
  • Published 1 October 2002
  • Medicine
  • Current Diabetes Reports
Dietary fat has been implicated in the development of insulin resistance in both animals and humans. Most, although not all, studies suggest that higher levels of total fat in the diet result in greater whole-body insulin resistance. Although, in practice, obesity may complicate the relationship between fat intake and insulin resistance, clinical trials demonstrate that high levels of dietary fat can impair insulin sensitivity independent of body weight changes. In addition, it appears that… 
Determining the relationship between dietary carbohydrate intake and insulin resistance
TLDR
Current evidence supports FAO/WHO recommendations to maintain a high–carbohydrate diet with low–GI foods, and the relationships between carbohydrate and insulin sensitivity remains an important research area.
Nutritional Modulation of Insulin Resistance
TLDR
An update of the current literature regarding the role of nutrition in the modulation of insulin resistance is provided, which includes the discussion of weight-loss-independent metabolic effects of commonly used dietary concepts.
Trans fatty acids, insulin resistance, and type 2 diabetes.
TLDR
Although there is some support from observational and experimental studies for the hypothesis that high intakes of TFAs may increase the risk for type 2 diabetes, inconsistencies across studies and methodological problems make it premature to draw definitive conclusions at this time.
Diet & insulin resistance: a review & Asian Indian perspective.
TLDR
Evidence linking dietary nutrients with insulin resistance and its metabolic correlates is presented, and data suggest that dietary omega-3 polyunsaturated fatty acids (PUFAs) improve lipid profile and may have beneficial effect on insulin resistance.
Insulin Resistance: Causes And Metabolic Implications
TLDR
High plasma levels of Insulin and glucose due to Insulin resistance often lead to metabolic syndrome and type 2 diabetes mellitus, and it is claimed that insulin resistance might be caused by a high carbohydrate diet.
Fish oil and olive oil can modify insulin resistance and plasma desacyl-ghrelin in rats
TLDR
Fish and olive oils may contribute to lower insulin level and HOMA-IR by increasing DAG concentration and may have more health benefits than other fat sources in diets.
Vascular Inflammation, Insulin Resistance, and Reduced Nitric Oxide Production Precede the Onset of Peripheral Insulin Resistance
TLDR
During obesity induced by HF feeding, inflammation and insulin resistance develop in the vasculature well before these responses are detected in muscle, liver, or adipose tissue, suggesting that the vasulature is more susceptible than other tissues to the deleterious effects of nutrient overload.
Fat: The Good, the Bad, and the Ugly
A certain amount of dietary fat, particularly the essential n–3 and n–6 fatty acids, is necessary for normal physiological function. The major types of dietary fats are saturated fats (largely
The Role of Dietary Fat in Insulin Resistance and Type 2 Diabetes
TLDR
Dietary fat has a role in both the etiology and prevention of insulin resistance and type 2 diabetes and the role of dietary fat is controversial as fatty acids act as signaling molecules in a variety of metabolic pathways.
Dietary fat intake and insulin resistance in black and white children.
TLDR
Findings support current AMDR guidelines for dietary fat in black children and adolescents, and the mechanism(s) underlying the ethnic differences in the relationship between dietary fat intake and SI in children require further investigation.
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 48 REFERENCES
Dietary fat and insulin action in humans
  • B. Vessby
  • Biology, Medicine
    British Journal of Nutrition
  • 2000
TLDR
It is suggested that a high proportion of fat in the diet is associated with impaired insulin sensitivity and an increased risk of developing diabetes, independent of obesity and body fat localization, and that this risk may be influenced by the type of fatty acids in the diets.
Dietary treatment of the metabolic syndrome — the optimal diet
TLDR
A large, multicentre intervention study in 162 healthy individuals shows that a high-monounsaturated-fat diet significantly improves insulin sensitivity compared to a highThe diet for the treatment of the metabolic syndrome should be limited in the intake of saturated fat, while high fibre/low-glycaemic-index foods should be used without specific limitations.
Diet composition and insulin action in animal models
TLDR
It has been clear for some time that ‘oils ain't oils’, the same is now proving true for carbohydrates and proteins, and increased PUFA intake in animal models is associated with improved insulin action and reduced adiposity.
Usual Dietary Fat Intake and Insulin Concentrations in Healthy Women Twins
TLDR
High intake of total dietary fat is positively related to relative fasting hyperinsulinemia in nondiabetic women, particularly those who are sedentary, and this effect appears to be partly mediated by the relation of dietary fat with obesity.
Dietary fat content alters insulin-mediated glucose metabolism in healthy men.
TLDR
A high-fat, low-carbohydrate intake reduces the ability of insulin to suppress endogenous glucose production and alters the relation between oxidative and nonoxidative glucose disposal in a way that favors storage of glucose.
Relationship of dietary fat and serum cholesterol ester and phospholipid fatty acids to markers of insulin resistance in men and women with a range of glucose tolerance.
TLDR
Self-reported intake of saturated and monounsaturated fats, but not trans fatty acids, are associated with markers of insulin resistance.
Comparison of the effects on insulin sensitivity of high carbohydrate and high fat diets in normal subjects.
TLDR
It is suggested that practically achievable high carbohydrate diets do not enhance insulin sensitivity in nondiabetic subjects and have net effects on lipoprotein metabolism that may be unfavorable.
Dietary fat and insulin sensitivity in a triethnic population: the role of obesity. The Insulin Resistance Atherosclerosis Study (IRAS)
TLDR
Among individuals already at increased risk for non-insulin-dependent diabetes mellitus because of obesity, high intake of dietaryFat may worsen insulin sensitivity, and this effect may be mediated by the relation of dietary fat to obesity.
Hypotensive effect of low-fat, high-carbohydrate diet can be independent of changes in plasma insulin concentrations.
TLDR
The results suggest that the hypotensive effects of a low-fat, high-carbohydrate diet, although associated with an improvement in insulin sensitivity, are not mediated by changes in plasma insulin concentration.
Effect of a controlled high-fat versus low-fat diet on insulin sensitivity and leptin levels in African-American and Caucasian women.
TLDR
It is concluded that a HF diet consumed over several weeks reduces S(I) in healthy women of both races; however, the magnitude of increase in S( I) on a LF diet is greater in Caucasian women.
...
1
2
3
4
5
...