The influence of dietary fat on insulin resistance

@article{Lovejoy2002TheIO,
  title={The influence of dietary fat on insulin resistance},
  author={Jennifer C. Lovejoy},
  journal={Current Diabetes Reports},
  year={2002},
  volume={2},
  pages={435-440}
}
  • J. Lovejoy
  • Published 1 October 2002
  • Medicine, Biology
  • Current Diabetes Reports
Dietary fat has been implicated in the development of insulin resistance in both animals and humans. Most, although not all, studies suggest that higher levels of total fat in the diet result in greater whole-body insulin resistance. Although, in practice, obesity may complicate the relationship between fat intake and insulin resistance, clinical trials demonstrate that high levels of dietary fat can impair insulin sensitivity independent of body weight changes. In addition, it appears that… 
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173 Citations
Highly Influential Citations
4
Background Citations
76
Methods Citations
4
Results Citations
6

173 Citations

Determining the relationship between dietary carbohydrate intake and insulin resistance

Current evidence supports FAO/WHO recommendations to maintain a high–carbohydrate diet with low–GI foods, and the relationships between carbohydrate and insulin sensitivity remains an important research area.

Nutritional Modulation of Insulin Resistance

An update of the current literature regarding the role of nutrition in the modulation of insulin resistance is provided, which includes the discussion of weight-loss-independent metabolic effects of commonly used dietary concepts.

Diet & insulin resistance: a review & Asian Indian perspective.

Evidence linking dietary nutrients with insulin resistance and its metabolic correlates is presented, and data suggest that dietary omega-3 polyunsaturated fatty acids (PUFAs) improve lipid profile and may have beneficial effect on insulin resistance.

Insulin Resistance: Causes And Metabolic Implications

High plasma levels of Insulin and glucose due to Insulin resistance often lead to metabolic syndrome and type 2 diabetes mellitus, and it is claimed that insulin resistance might be caused by a high carbohydrate diet.

Fish oil and olive oil can modify insulin resistance and plasma desacyl-ghrelin in rats

Fish and olive oils may contribute to lower insulin level and HOMA-IR by increasing DAG concentration and may have more health benefits than other fat sources in diets.

Vascular Inflammation, Insulin Resistance, and Reduced Nitric Oxide Production Precede the Onset of Peripheral Insulin Resistance

During obesity induced by HF feeding, inflammation and insulin resistance develop in the vasculature well before these responses are detected in muscle, liver, or adipose tissue, suggesting that the vasulature is more susceptible than other tissues to the deleterious effects of nutrient overload.

Fat: The Good, the Bad, and the Ugly

In general, saturated fats and trans fats have an adverse effect on health risk factors, while n–3 polyunsaturated fatty acids have beneficial effects on multiple risk factors.

The Role of Dietary Fat in Insulin Resistance and Type 2 Diabetes

Dietary fat has a role in both the etiology and prevention of insulin resistance and type 2 diabetes and the role of dietary fat is controversial as fatty acids act as signaling molecules in a variety of metabolic pathways.

Dietary fat intake and insulin resistance in black and white children.

Findings support current AMDR guidelines for dietary fat in black children and adolescents, and the mechanism(s) underlying the ethnic differences in the relationship between dietary fat intake and SI in children require further investigation.

Study of comparative effects of antioxidants on insulin sensitivity in type 2 diabetes mellitus.

ALA, omega 3 fatty acids and vitamin E showed the improvement in insulin sensitivity, and all of these three can be used as an add on therapy in patients with type 2 diabetes mellitus to improve their insulin sensitivity and lipid metabolism.
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References

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  • Medicine, Biology
    British Journal of Nutrition
  • 2000
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