The influence of dietary fat on insulin resistance

  title={The influence of dietary fat on insulin resistance},
  author={Jennifer C. Lovejoy},
  journal={Current Diabetes Reports},
  • J. Lovejoy
  • Published 1 October 2002
  • Medicine, Biology
  • Current Diabetes Reports
Dietary fat has been implicated in the development of insulin resistance in both animals and humans. Most, although not all, studies suggest that higher levels of total fat in the diet result in greater whole-body insulin resistance. Although, in practice, obesity may complicate the relationship between fat intake and insulin resistance, clinical trials demonstrate that high levels of dietary fat can impair insulin sensitivity independent of body weight changes. In addition, it appears that… 

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Diet & insulin resistance: a review & Asian Indian perspective.

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Insulin Resistance: Causes And Metabolic Implications

High plasma levels of Insulin and glucose due to Insulin resistance often lead to metabolic syndrome and type 2 diabetes mellitus, and it is claimed that insulin resistance might be caused by a high carbohydrate diet.

Fish oil and olive oil can modify insulin resistance and plasma desacyl-ghrelin in rats

Fish and olive oils may contribute to lower insulin level and HOMA-IR by increasing DAG concentration and may have more health benefits than other fat sources in diets.

Vascular Inflammation, Insulin Resistance, and Reduced Nitric Oxide Production Precede the Onset of Peripheral Insulin Resistance

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Fat: The Good, the Bad, and the Ugly

In general, saturated fats and trans fats have an adverse effect on health risk factors, while n–3 polyunsaturated fatty acids have beneficial effects on multiple risk factors.

The Role of Dietary Fat in Insulin Resistance and Type 2 Diabetes

Dietary fat has a role in both the etiology and prevention of insulin resistance and type 2 diabetes and the role of dietary fat is controversial as fatty acids act as signaling molecules in a variety of metabolic pathways.

Dietary fat intake and insulin resistance in black and white children.

Findings support current AMDR guidelines for dietary fat in black children and adolescents, and the mechanism(s) underlying the ethnic differences in the relationship between dietary fat intake and SI in children require further investigation.

Study of comparative effects of antioxidants on insulin sensitivity in type 2 diabetes mellitus.

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Dietary fat and insulin action in humans

  • B. Vessby
  • Medicine, Biology
    British Journal of Nutrition
  • 2000
It is suggested that a high proportion of fat in the diet is associated with impaired insulin sensitivity and an increased risk of developing diabetes, independent of obesity and body fat localization, and that this risk may be influenced by the type of fatty acids in the diets.

Dietary treatment of the metabolic syndrome — the optimal diet

A large, multicentre intervention study in 162 healthy individuals shows that a high-monounsaturated-fat diet significantly improves insulin sensitivity compared to a highThe diet for the treatment of the metabolic syndrome should be limited in the intake of saturated fat, while high fibre/low-glycaemic-index foods should be used without specific limitations.

Diet composition and insulin action in animal models

It has been clear for some time that ‘oils ain't oils’, the same is now proving true for carbohydrates and proteins, and increased PUFA intake in animal models is associated with improved insulin action and reduced adiposity.

Usual Dietary Fat Intake and Insulin Concentrations in Healthy Women Twins

High intake of total dietary fat is positively related to relative fasting hyperinsulinemia in nondiabetic women, particularly those who are sedentary, and this effect appears to be partly mediated by the relation of dietary fat with obesity.

Dietary fat content alters insulin-mediated glucose metabolism in healthy men.

A high-fat, low-carbohydrate intake reduces the ability of insulin to suppress endogenous glucose production and alters the relation between oxidative and nonoxidative glucose disposal in a way that favors storage of glucose.

Relationship of dietary fat and serum cholesterol ester and phospholipid fatty acids to markers of insulin resistance in men and women with a range of glucose tolerance.

Self-reported intake of saturated and monounsaturated fats, but not trans fatty acids, are associated with markers of insulin resistance.

Comparison of the effects on insulin sensitivity of high carbohydrate and high fat diets in normal subjects.

It is suggested that practically achievable high carbohydrate diets do not enhance insulin sensitivity in nondiabetic subjects and have net effects on lipoprotein metabolism that may be unfavorable.

Dietary fat and insulin sensitivity in a triethnic population: the role of obesity. The Insulin Resistance Atherosclerosis Study (IRAS)

Among individuals already at increased risk for non-insulin-dependent diabetes mellitus because of obesity, high intake of dietaryFat may worsen insulin sensitivity, and this effect may be mediated by the relation of dietary fat to obesity.

Hypotensive effect of low-fat, high-carbohydrate diet can be independent of changes in plasma insulin concentrations.

The results suggest that the hypotensive effects of a low-fat, high-carbohydrate diet, although associated with an improvement in insulin sensitivity, are not mediated by changes in plasma insulin concentration.