The influence of dietary creatine supplementation on performance during repeated bouts of maximal isokinetic cycling in man

  title={The influence of dietary creatine supplementation on performance during repeated bouts of maximal isokinetic cycling in man},
  author={Robert Birch and Denis Noble and Paul L. Greenhaff},
  journal={European Journal of Applied Physiology and Occupational Physiology},
The effect of dietary creatine (Cr) supplementation on performance during 3, 30 s bouts maximal isokinetic cycling and on plasma ammonia and blood lactate accumulation during exercise was investigated. Placebo (P) ingestion had no effect on peak power output (PPO), mean power output (MPO) and total work output during each bout of exercise. Cr ingestion (4 × 5−1 for 5 days) significantly increased PPO in exercise bout 1 (p<0.05) and IMO and total work output in exercise bouts 1 (p<0.05, p… 
Effect of creatine supplementation on aerobic performance and anaerobic capacity in elite rowers in the course of endurance training.
It is indicated that in elite rowers, creatine supplementation improves endurance (expressed by the individual lactate threshold) and anaerobic performance, independent of the effect of intensive endurance training.
Effect of Creatine Supplementation on Aerobic Performance and Anaerobic Capacity in Bite Rowers in the Course of Endurance Training
The effect of oral creatine supplementation on aerobic and anaerobic performance was investigated in 16 elite male rowers during 7-day endurance training. Before and after the daily ingestion of20 g
Effect of creatine supplementation on oxygen uptake kinetics during submaximal cycle exercise.
The magnitude of the reduction in submaximal VO(2) with Cr loading was significantly correlated with the percentage of type II fibers in the vastus lateralis, indicating that the effect might be related to changes in motor unit recruitment patterns or the volume of muscle activated.
The effects of creatine pyruvate and creatine citrate on performance during high intensity exercise
It is concluded that four weeks of Cr-Pyr and Cr-Cit intake significantly improves performance during intermittent handgrip exercise of maximal intensity and that Cr- Pyr might benefit endurance, due to enhanced activity of the aerobic metabolism.
Oral creatine supplementation's decrease of blood lactate during exhaustive, incremental cycling.
It is demonstrated that creatine supplementation decreases lactate during incremental cycling exercise and tends to raise lactate threshold, therefore, creatine supplementation could potentially benefit endurance athletes.
Effect of creatine supplementation on phosphocreatine resynthesis, inorganic phosphate accumulation and pH during intermittent maximal exercise
The better maintenance of muscle power output observed after creatine ingestion was attributed to a higher rate of phosphocreatine resynthesis, lower accumulation of inorganic phosphate and higher pH.
Effects of creatine loading and prolonged creatine supplementation on body composition, fuel selection, sprint and endurance performance in humans.
There is definite evidence that prolonged creatine supplementation in humans does not increase muscle or whole-body oxidative capacity and, as such, does not influence substrate utilization or performance during endurance cycling exercise.
It is suggested that no performance advantage was gained from the addition of carbohydrate to a creatine-loading regimen in these high-caliber swimmers.
Creatine supplementation and performance in 6 consecutive 60 meter sprints
The results indicate that creatine monohydrate supplementation does not appear to improve the performance in 6 consecutive 60 meter repeated races but may modify ventilatory dynamics during the recovery after maximal effort.
The use of varying creatine regimens on sprint cycling.
The data indicate that a 100g compared to 40g ACRL produces a greater potentiation of performance whilst, greater quantities of creatine ingestion (135gACRL) can not provide a greater benefit.


Influence of oral creatine supplementation of muscle torque during repeated bouts of maximal voluntary exercise in man.
Investigation of the influence of oral creatine supplementation on skeletal muscle isokinetic torque and the accumulation of plasma ammonia and blood lactate during five bouts of maximal exercise found muscle peak torque production was greater and plasma ammonia accumulation was lower during and after exercise after creatine ingestion.
Muscle power and metabolism in maximal intermittent exercise.
Changes in muscle glycogen, lactate, and glycolytic intermediates suggested rate limitation at phosphofructokinase during the first and second exercise periods, and phosphorylase in the third and fourth exercise periods.
Elevation of creatine in resting and exercised muscle of normal subjects by creatine supplementation.
Competition with 5g of creatine monohydrate, four or six times a day for 2 or more days resulted in a significant increase in the total creatine content of the quadriceps femoris muscle measured in 17 subjects, and in some the increase was as much as 50%.
Effect of oral creatine supplementation on skeletal muscle phosphocreatine resynthesis.
The data suggest that a dietary-induced increase in muscle total Cr concentration can increase PCr resynthesis during the 2nd min of recovery from intense contraction.
Creatine supplementation and dynamic high‐intensity intermittent exercise
The mechanism responsible for the improved performance with creatine supplementation are postulated to be both a higher initial creatine phosphate content availability and an increased rate of creatine phosphate resynthesis during recovery periods, and the lower blood lactate and hypoxanthine accumulation can be explained by these mechanisms.
Muscle ATP loss and lactate accumulation at different work intensities in the exercising Thoroughbred horse
The results suggest that peak accumulation of any of these, or simply the concentration at a specified recovery time, may be used as a measure of ATP loss in the musculature as a whole, and that xanthine may be formed from the degradation of guanidine nucleotides.
A constant-velocity cycle ergometer for the study of dynamic muscle function.
The peak torque-velocity relationship and the percentage decline in peak torque during 30 s exercise at 60, 100, and 140 rpm were reproducible within a given subject, the coefficient of variation was less than 10%.
Supplementary creatine as a treatment for gyrate atrophy of the choroid and retina.
Fundus photography revealed slow impairment at an age otherwise associated with rapid progression of the disease, and promising preliminary results need further evaluation with long-term follow-up studies.
The influence of oral creatine supplementation on muscle phosphocreatine resynthesis following intense contraction in man
  • Am J Physiol, 266: E725-730.
  • 1994
Energy metabolism and fatigue
  • In: Taylow AW, Golinick PD, Green HJ, Ianuzzo CD, Noble EG, Metivier G, Sutton JR (eds) Biochemistry of Exercise VII, Human Kinetics Publishers, Champaign, IL, USA, pp 73-92.
  • 1990