The influence of dicoumarol on the bioactivation of the carcinogen aristolochic acid I in rats.

Abstract

UNLABELLED Aristolochic acid I (AAI) is the major toxic component of the plant extract AA, which leads to the development of nephropathy and urothelial cancer in human. Individual susceptibility to AAI-induced disease might reflect variability in enzymes that metabolise AAI. In vitro NAD(P)H quinone oxidoreductase (NQO1) is the most potent enzyme that… (More)
DOI: 10.1093/mutage/geu004

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@article{Stiborov2014TheIO, title={The influence of dicoumarol on the bioactivation of the carcinogen aristolochic acid I in rats.}, author={Marie Stiborov{\'a} and Kateřina Levov{\'a} and Franti{\vs}ek B{\'a}rta and Miroslav Sulc and Eva Frei and Volker M Arlt and Heinz Hans Schmeiser}, journal={Mutagenesis}, year={2014}, volume={29 3}, pages={189-200} }