The influence of diabetes on cardiac β-adrenoceptor subtypes

  title={The influence of diabetes on cardiac β-adrenoceptor subtypes},
  author={Vecdi Melih Altan and Ebru Arioğlu and Sahika Guner and Arif Tanju Ozcelikay},
  journal={Heart Failure Reviews},
Despite the significant developments in the treatment of diabetes mellitus, diabetic patients still continue to suffer from cardiac complications. The increase of cardiac adrenergic drive may ultimately contribute to the development and progression of diabetic cardiomyopathy. β-Adrenoceptors play an important role in the regulation of heart function. However, responsiveness of diabetic heart to β-adrenoceptor agonist stimulation is diminished. The chronotropic responses mediated by β1-subtype… CONTINUE READING