The influence of dextromethorphan on morphine analgesia in Swiss Webster mice is sex-specific

@article{Grisel2005TheIO,
  title={The influence of dextromethorphan on morphine analgesia in Swiss Webster mice is sex-specific},
  author={Judith E Grisel and Stephani S Allen and Kumar Venkata Subrahmanya Nemmani and Jon R Fee and Richard D S Carliss},
  journal={Pharmacology Biochemistry and Behavior},
  year={2005},
  volume={81},
  pages={131-138}
}
NMDA (N-methyl-d-aspartate) antagonists are known to enhance the analgesic effects of opioids. However, virtually, all studies of this phenomenon have been done using male subjects. Here, the noncompetitive NMDA receptor antagonist dextromethorphan (DEX) was tested over a range of doses (10-200 microg intracerebroventricularly [i.c.v.]) in male and female Swiss Webster mice in combination with 5 mg/kg intraperitoneal (i.p.) morphine. Males exhibited enhanced morphine analgesia following either… CONTINUE READING

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