The influence of collagen-glycosaminoglycan scaffold relative density and microstructural anisotropy on tenocyte bioactivity and transcriptomic stability.

@article{Caliari2012TheIO,
  title={The influence of collagen-glycosaminoglycan scaffold relative density and microstructural anisotropy on tenocyte bioactivity and transcriptomic stability.},
  author={Steven R. Caliari and Daniel W. Weisgerber and Manuel G Ram{\'i}rez and Douglas O Kelkhoff and Brendan A C Harley},
  journal={Journal of the mechanical behavior of biomedical materials},
  year={2012},
  volume={11},
  pages={27-40}
}
Biomaterials for orthopedic tissue engineering must balance mechanical and bioactivity concerns. This work describes the fabrication of a homologous series of anisotropic collagen-GAG (CG) scaffolds with aligned tracks of ellipsoidal pores but increasing relative densities (ρ(∗)/ρ(s)), and we report the role scaffold relative density plays in directing tenocyte bioactivity. Scaffold permeability and mechanical properties, both in tension and compression, were significantly influenced by… CONTINUE READING
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