The influence of clinical and anthropometric parameters on the serum levels of the endothelin-1 in pregnant women and their newborns.

Abstract

Pregnancy induced hypertension (PIH) is major contributor to maternal death in developing countries. Endothelin-1 (ET-1) is the most potent vasoconstriction agent known and its serum levels are increased in PIH. Therefore it is important to elucidate maternal and neonatal factors which influence endothelin-1 serum levels. 100 pathological pregnancies and 88 controls were analyzed for blood endothelin-1 and their anthropometric and clinical data were collected. In maternal blood ET-1 levels were strongly predicted by diagnosis, therapy and BMI, while umbilical cord ET-1 levels were strongly predicted by gestational age, therapy and delivery termination. Positive correlation between BMI and ET-1 levels suggest that obese pregnant women have increased risk for cardiovascular diseases. Inverse relationship between Apgar and umbilical ET-1 indicates that ET-1 could be considered as a prognostic marker in cases of neonatal asphyxia.

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Cite this paper

@article{Saruni2012TheIO, title={The influence of clinical and anthropometric parameters on the serum levels of the endothelin-1 in pregnant women and their newborns.}, author={Alenka Vukeli{\'c} Saruni{\'c} and Olga Cvijanovi{\'c} and Luka Dudari{\'c} and Branko Denona and Lucian Vukeli{\'c} and Dragica Bobinac and Aleks Finderle}, journal={Collegium antropologicum}, year={2012}, volume={36 2}, pages={395-400} }