The influence of cimetidine on debrisoquine 4-hydroxylation in extensive metabolizers

@article{Philip1989TheIO,
  title={The influence of cimetidine on debrisoquine 4-hydroxylation in extensive metabolizers},
  author={Philip Agop Philip and Christopher A. James and Howard J. Rogers},
  journal={European Journal of Clinical Pharmacology},
  year={1989},
  volume={36},
  pages={319-321}
}
We have studied the effect of cimetidine (800 mg·day−1) administration for three days on debrisoquine 4-hydroxylation in nine healthy extensive metabolizers. The debrisoquine metabolic ratio was significantly increased (p<0.01), but the new ratios remained in the extensive metabolizer range (<12.6). These data suggest that pre-treatment with cimetidine in usual therapeutic doses will impair debrisoquine 4-hydroxylation, but not enough to alter the apparent oxidation phenotype. 

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