The influence of cimetidine on debrisoquine 4-hydroxylation in extensive metabolizers

  title={The influence of cimetidine on debrisoquine 4-hydroxylation in extensive metabolizers},
  author={Philip Agop Philip and Christopher A. James and Howard J. Rogers},
  journal={European Journal of Clinical Pharmacology},
We have studied the effect of cimetidine (800 mg·day−1) administration for three days on debrisoquine 4-hydroxylation in nine healthy extensive metabolizers. The debrisoquine metabolic ratio was significantly increased (p<0.01), but the new ratios remained in the extensive metabolizer range (<12.6). These data suggest that pre-treatment with cimetidine in usual therapeutic doses will impair debrisoquine 4-hydroxylation, but not enough to alter the apparent oxidation phenotype. 

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Gene - tically determined oxidation capacity and the disposition of de - brisoquine

A Somogyi, M Muirhead
Br J Clin Pharmacol • 1987

Oxidation of tricyclic

M son, E Spina, K Woodhouse

duction of metformin renal excretion by cimetidine in man

E Steiner, L Iselius, G Alvan, J Lindsten, F Sjrqvist
Br J Clin Pharmacol • 1985

Aberg-Wistedt A (1983) The debrisoquine hydroxylation test predicts steady-state plasma levels of desipramine

L Bertilsson
Br J Clin Pharmacol • 1983

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